Prescription Drug Therapy

While medications are often prescribed for OAB, several classes of medicines for other conditions may cause unwanted changes in bladder control. When discussing symptoms, be sure to mention to your doctor if your taking other medications.

Anticholinergics: Drugs with anticholinergic and bladder muscle relaxant effects are often prescribed to relieve symptoms of urgency and frequency.These drugs may have side-effects including dry mouth, constipation, blurred vision, gastroesophageal reflux, and urinary retention. To minimize side-effects, extended-release formulations and non-oral alternatives for drug delivery have been developed.

Beta-3 adrenergic receptor: The FDA has recently approved once daily Myrbetriq™ (mirabegron) , pronounced meer-BEH-trick, for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and urinary frequency. Myrbetriq™ extended release tablets are the first and only beta-3 andrenergic agonist approved for the treatment of overactive bladder.  Myrbetriq works by relaxing the detrusor smooth muscle during the storage phase of the urinary bladder fill-void cycle by activation of beta-3 adrenergic receptors which increase bladder capacity.

Ongoing research demonstrates that combining behavioral therapies with medication is more effective in treating OAB and urgency incontinence than either behavioral therapy or taking medication alone.